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发布于:2018-9-25 07:31:27  访问:4 次 回复:0 篇
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Various Chilling Yet Exciting CASK Ideas
Patients relapsing later and without the possibility of NMA can CASK be treated for long periods with other low-toxicity monotherapy, such as vinblastine, brentuximab vedotin, panobinostat, bendamustine or gemcitabine (Brice, 2008; Younes et?al, 2012; Moskowitz et?al, 2013). In a non-curative approach, these molecules could be given alternately. When intensification is possible, by radiotherapy or NMT allotransplant, PLD could be combined with these agents. The effect and possible synergism of these combinations needs to be confirmed in the future by multicentric clinical trials, to determine the best regimen to be used. T.C. and P.B. wrote the paper; T.C., P.B., C.T., I.M., P.F., M.R., E.K., B.D. performed the Voxtalisib supplier research; J.B. and C.B. undertook the pathological review; and T.C. and P.B. analysed the results and produced the figures. "" A 76-year-old man was admitted to our hospital because of fever, weight loss and night sweats. Abdominal examination revealed marked hepatosplenomegaly but no peripheral lymphadenopathy. The results of his blood analysis were as follows: white blood cell count, 4��46?��?109/l (69��5% neutrophils, 13��5% lymphocytes and 15��5% monocytes); haemoglobin, 103?g/l; platelet count, 333?��?109/l; lactate dehydrogenase, 476?iu/l; and C-reactive protein, 195��6?mg/l. Plasma levels of macrophage colony-stimulating factor (M-CSF) were elevated to 608?pg/ml (normal: <373?pg/ml). Computed tomography Tigecycline mw scans showed a tumour mass in the anterior mediastinum and left diaphragm, hepatosplenomegaly and multiple splenic lesions, the largest of which was 5��0?��?5��3?��?5��0?cm. A splenectomy was performed for diagnostic purposes. Histological examination of the spleen showed diffuse proliferation of large lymphoid cells that totally effaced the organ��s architecture (left; haematoxylin & eosin). Abnormal cells were positive for M-CSF (EP1179Y; LifeSpan Biosciences, Seattle, WA, USA) (right). Epstein�CBarr-encoded RNA in situ hybridization was negative. Southern blot analysis showed a clonal rearrangement of the immunoglobulin heavy chain gene. These findings were consistent with diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), stage IIIsB. The M-CSF plasma level decreased to 454?pg/ml following treatment with two courses of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) therapy, and after three courses, the patient��s clinical symptoms, lymphoma lesions and monocytosis disappeared, with a white blood cell count of 5��62?��?109/l (61% neutrophils, 32% lymphocytes and 4��5% monocytes). This case clearly demonstrates production of M-CSF by neoplastic cells of DLBCL with chemotherapy-induced reduction in tumour size being paralleled by a fall in the monocyte count.
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